pecunium: (Default)
I did some research on grapefruit juice and opiates:

All in all, I'd say give the juice a pass.

WASHINGTON (Reuters) - U.S. researchers said they have identified the compound in grapefruit juice that affects how some drugs are absorbed in the body and said on Tuesday it might be used to help lower dosages for some patients.

Grapefruit juice is known for its effects on drug metabolism and is avoided by some patients while other deliberately take their drugs with the juice.

The reason is an intestinal enzyme called CYP3A, which partially destroys drugs as they are absorbed. Grapefruit juice, like no other fruit juice, interferes with CYP3A, so the body ends up absorbing more of the drug.

Dr. Paul Watkins of the University of North Carolina at Chapel Hill and colleagues say they have identified the substance in grapefruit juice that is responsible -- furanocoumarin.

"It should now be possible to market the furanocoumarin-free grapefruit juice to patients who would otherwise need to avoid grapefruit," Watkins said in a statement.

"In addition, it should be possible to screen new foods for the potential for drug interactions by determining whether they contain furanocoumarins," Watkins said.

"Finally, it may be possible to add furanocoumarins to formulations of certain drugs that tend to be poorly or erratically absorbed to improve their oral delivery."

To test the theory that furanocoumarin was the responsible compound, Watkins and colleagues filtered it out grapefruit juice, which they discovered was then less bitter but otherwise unaltered.

Then they tested 18 men and women taking various drugs on a regular basis including aspirin and birth control pills.

Each fasted in the hospital and got a single dose of the blood pressure drug felopidine, sold under the brand name Plendil, along with either normal grapefruit juice, furanocoumarin-free juice or orange juice.

They then ate and drank normally and blood was taken regularly all day.

In each volunteer, the normal grapefruit juice made between 6 percent to 230 percent more Plendil available in the blood, the researchers reported in the American Journal of Clinical Nutrition. The furanocoumarin-free grapefruit juice and orange juice had no such effect, they reported.

The range of effect is really large, which is why I'd say give it a pass. My guess, based on my urination pattern isn't that percoset was a diuretic, so much as it as something my kidneys wanted to get rid of. If the grapefruit juice was allowing a really large amount into my system, I had a lot to dispose of. In any case I am feeling a lot better today, though I seem to be a bit behind the curve on controlling the pain. I'm eating, and changing my fluids, and we'll see how it shakes out.


Jan. 21st, 2011 10:42 pm
pecunium: (camo at halloween)
Percocet has a side effect (at least for me): It's a potent diuretic. I spent this afternoon struggling with dehydration. I spotted it coming on, but I was behind the curve. I drank fluids, I had chicken soup, etc.

But I kept having to hit the toilet, it wasn't ever very much, but it seems to have added up; and it as basically clear.

By noon I was in agony. The back of my neck was in pain. I was vertigonous (all the more exciting when one on cructhes). I was nauseated. Someone was taking a trowel and trying to pry my sinuses out of their sockets.

I drank more grapefruit juice. I lay on my side and pondered being dead. I wondered if the percocet was able to dry me out enough to kill me. I thought that might not be so bad.

I managed to fall asleep.

Sleep, and fluids, have always been required for me to recover from dehydration. I'm in much better shape. I ate some ice cream when I woke up. Still a bit groggy, and a bit achey in the neck, but my eyes aren't wincing at the light, no one is trying to rips parts of my face out of my skull and I don't feel that I'll fall when I move.

[personal profile] savorie came over, and took me out to dinner. Then we went and did some shopping. I introduced her to an Israeli chocolate, and we sat around schmoosing when she dropped me off.

Now I intend to drink some more fluids, put my ankle on a bag of peas and go to sleep. If I need it, I'll pop a percoset, but only if the pain starts edging past four. Until I feel overhydrated, I don't want to let it run through my system when I can't pour some liquids down my throat.


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